Author

P. J. van Diest

Primary ORCID profile (0000-0003-0658-2745 · 3 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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P. J. van DiestiD3 papers · University Medical Center Utrecht

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Gorthi· 1 shared A. J. Bishop· 1 shared A. van Brussel· 1 shared A. van de Stolpe· 1 shared B. A. Wilky· 1 shared C. B. Moelans· 1 shared C. Veldman· 1 shared D. M. Loeb· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Gorthi

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Author profile →

3 papers

Recent·Most cited

Somatic mutation of Afadin leads to anchorage independent survival and metastatic growth of breast cancer through alpha E-catenin dependent destabilization of the adherens junction

M. A. Ratze, L. N. Enserink, N. Ishiyama, C. Veldman, I. J. Nijman, R. R. Bernards, P. J. van Diest, M. Christgen, P. W. Derksen

This study identifies a somatic Afadin mutation that destabilizes adherens junctions and promotes metastatic growth in breast cancer by disrupting E-catenin binding.

bioRxiv · Jul 4, 2023 · PreprintCancer Biology

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

M. E. Randolph, M. Afifi, A. Gorthi, R. Weil, B. A. Wilky, J. Weinreb, P. Ciero, N. ter Hoeve, P. J. van Diest, V. Raman, A. J. Bishop, D. M. Loeb

This study shows DDX3 regulates RAD51 localization and DNA damage repair in Ewing sarcoma, enhancing radiosensitivity when DDX3 is inhibited.

bioRxiv · Jun 10, 2023Cancer Biology

Heterogeneity in signaling pathway activity within primary and between primary and metastatic breast cancer

M. A. Inda, P. van Swinderen, A. van Brussel, C. B. Moelans, W. Veraheagh, H. van Zon, E. C. den Biezen-Timmermans, J. W. Bikker, P. J. van Diest, A. van de Stolpe

This study measures signaling pathway activity in breast cancer samples to assess heterogeneity within primary tumors and between primary and metastatic sites, finding that microscale variation is higher in some pathways and that metastases show less correlation with primary tumors.

bioRxiv · Jul 27, 2020Cancer Biology