Cardiac Cell-Derived Matrices Impart Age-Specific Functional Properties to Human Cardiomyocytes
M. A. Kauss, S. J. Rockwood, A. C. Silva, D. A. Joy, N. Mendoza-Camacho, M. N. Whittaker, E. Stevenson, N. J. Krogan, D. L. Swaney, T. C. McDevitt
The paper develops a method to create stable cardiac cell-derived matrices and shows that fetal and adult matrices impart distinct functional properties to cardiomyocytes, with collagen VI in fetal matrices enhancing oxidative respiration.
bioRxiv · Jul 31, 2020 · PreprintCell Biology