Rapid Loss of CD4 T Cells by Pyroptosis During Acute SIV Infection in Rhesus Macaques
X. He, M. Aid, J. Ventura, E. Borducchi, M. A. Lifton, J. Liu, D. H. Barouch
This study identifies pyroptosis as the main cause of CD4 T cell loss in acute SIV infection in rhesus macaques, with IFI16 upregulation linked to viral loads and cell depletion.
bioRxiv · May 24, 2022Microbiology