Author

M. A. McCool

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. J. Bryant· 3 shared L. Abriola· 3 shared S. J. Baserga· 3 shared Y. V. Surovtseva· 3 shared A. F. Buhagiar· 1 shared G. T. Rosado-Gonzalez· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

C. J. Bryant

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Author profile →

3 papers

Recent·Most cited

Discovery of novel microRNA mimic repressors of ribosome biogenesis

C. J. Bryant, M. A. McCool, G. T. Rosado-Gonzalez, L. Abriola, Y. V. Surovtseva, S. J. Baserga

The paper identifies 72 novel microRNA repressors of ribosome biogenesis through high-content screening and validation, revealing their impact on pre-rRNA processing and protein synthesis.

bioRxiv · Feb 17, 2023Biochemistry

Human pre-60S assembly factors link rRNA transcription to pre-rRNA processing

A. F. Buhagiar, M. A. McCool, C. J. Bryant, L. Abriola, Y. V. Surovtseva, S. J. Baserga

This study identifies RSL24D1 and the PeBoW complex as essential for pre-rRNA transcription and processing, linking ribosome biogenesis to rDNA transcription.

bioRxiv · Mar 1, 2022 · PreprintBiochemistry

A high-throughput assay for directly monitoring nucleolar rRNA biogenesis

C. J. Bryant, M. A. McCool, L. Abriola, Y. V. Surovtseva, S. J. Baserga

This paper introduces a high-throughput 5-EU assay to directly measure nucleolar rRNA biogenesis inhibition using fibrillarin co-staining, validated on 68 nucleolar hits.

bioRxiv · Jul 19, 2021Cell Biology