Therapeutic TNF-alpha Delivery After CRISPR Receptor Modulation in the Intervertebral Disc
J. D. Stover, M. A. R. Trone, J. Weston, C. Lewis, H. Levis, M. Philippi, M. Zeidan, B. Lawrence, R. D. Bowles
This study uses CRISPR to modulate TNFR1 in rats, reducing disc degeneration and showing that TNF-alpha injection becomes therapeutic after receptor modulation.
bioRxiv · May 31, 2023Bioengineering