Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity
H. Guo, E. L. Stamper, A. Sato-Carlton, M. A. Shimazoe, X. Li, L. Zhang, L. Stevens, K. J. Tam, A. F. Dernburg, P. M. Carlton
This study shows that phosphorylation of DSB-1 by PP4PPH-4.1 and ATRATL-1 regulates meiotic DSB levels in C. elegans, with DSB-2 compensating for age-related inactivation of DSB-1.
bioRxiv · Feb 16, 2022Cell Biology