A. F. Dernburg

Chemically induced proximity reveals mechanotransduction of a meiotic checkpoint at the nuclear envelope

The paper identifies a mechanosensitive channel, PEZO-1, that transduces signals from nuclear lamina destabilization to trigger apoptosis in C. elegans oocytes.

A novel meiotic protein required for homolog pairing and regulation of synapsis in C. elegans

This study identifies MJL-1 as a meiosis-specific protein essential for homolog pairing and synapsis in C. elegans by connecting Pairing Centers to LINC complexes.

Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

This study shows that phosphorylation of DSB-1 by PP4PPH-4.1 and ATRATL-1 regulates meiotic DSB levels in C. elegans, with DSB-2 compensating for age-related inactivation of DSB-1.

Robust, versatile DNA FISH probes for chromosome-specific repeats in Caenorhabditis elegans and Pristionchus pacificus

The paper designs and validates DNA FISH probes for chromosome-specific repeats in C. elegans and P. pacificus, enabling reliable fluorescent signals in various tissues.

DNA damage signaling regulates cohesin stabilization and promotes meiotic chromosome axis morphogenesis

The paper shows DNA damage response signaling stabilizes cohesin and promotes meiotic chromosome axis formation in C. elegans by downregulating WAPL-1 through ATM-1 phosphorylation.

A cooperative network at the nuclear envelope counteracts LINC-mediated forces during oogenesis in C. elegans

The paper investigates mechanical forces during oogenesis in C. elegans and finds that a lamin meshwork counteracts LINC-mediated forces to prevent nuclear collapse.

Recruitment of Polo-like kinase couples synapsis to meiotic progression via inactivation of CHK-2

The paper shows that PLK-2 inactivates CHK-2 in C. elegans to promote crossover formation and meiotic progression after synapsis.

Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

The paper analyzes meiosis in Pristionchus pacificus, showing that DMC-1 and RAD-51 have distinct roles in homolog pairing and synapsis compared to C. elegans.

A compartmentalized signaling network mediates crossover control in meiosis

This paper identifies a family of RING finger proteins in C. elegans that form a signaling network regulating crossover control during meiosis.

Super-resolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intact C. elegans tissue

The paper uses super-resolution microscopy to determine the 3D organization of meiotic chromosome axes in C. elegans, revealing distinct arrangements of cohesin complexes and HORMA-domain proteins.