Mycobacterial OtsA structures unveil substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate
V. Mendes, M. Acebron-Garcia-de-Eulate, N. Verma, M. Blaszczyk, M. V. B. Dias, T. L. Blundell
The paper reports the first mycobacterial OtsA structures from M. thermoresistibile, revealing substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate.
bioRxiv · Jul 5, 2019Biochemistry