Author

M. Blaszczyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. L. Blundell· 3 shared A. G. Coyne· 2 shared C. Abell· 2 shared C. Spry· 2 shared H. Abramczyk· 2 shared J. C. Evans· 2 shared M. Kopec· 2 shared M. Radek· 2 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

T. L. Blundell

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Author profile →

5 papers

Recent·Most cited

Raman imaging and statistical methods for analysis various type of human brain tumor

M. Kopec, M. Blaszczyk, M. Radek, H. Abramczyk

This study uses Raman imaging and statistical methods to identify biomarkers for distinguishing human brain tumor types, achieving over 85% sensitivity and specificity.

bioRxiv · Apr 8, 2021Cancer Biology

Redox Imbalance and Biochemical Changes in Cancer by probing redox-sensitive mitochondrial cytochromes in label-free visible resonance Raman imaging

H. Abramczyk, B. Brozek-Pluska, M. Kopec, M. Blaszczyk, M. Radek

This study uses Raman imaging to analyze redox state changes in mitochondrial cytochromes in human brain and breast cancers, correlating cytochrome redox status with malignancy grade.

bioRxiv · Dec 3, 2020Cancer Biology

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

J. El Bakali, M. Blaszczyk, J. C. Evans, J. A. Boland, W. J. McCarthy, M. V. B. Dias, A. G. Coyne, V. Mizrahi, T. L. Blundell, C. Abell, C. Spry

This study identifies inhibitors of MtbPPAT, a key enzyme in CoA biosynthesis, using fragment linking and CRISPR interference to validate it as a potential anti-TB drug target.

bioRxiv · Sep 4, 2020Biochemistry

Inhibiting Mycobacterium tuberculosis CoaBC by targeting a new allosteric site.

V. Mendes, S. R. Green, J. C. Evans, J. Hess, M. Blaszczyk, C. Spry, O. Bryant, J. Cory-Wright, D. S.-H. Chan, P. H. M. Torres, Z. Wang, S. O'Neill, S. Damerow, J. Post, T. Bayliss, , T. L. Blundell

The paper identifies potent inhibitors of Mycobacterium tuberculosis CoaB by targeting a novel allosteric site, based on structural and biochemical analyses of CoaBC.

bioRxiv · Jan 15, 2020 · PreprintBiochemistry

Mycobacterial OtsA structures unveil substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate

V. Mendes, M. Acebron-Garcia-de-Eulate, N. Verma, M. Blaszczyk, M. V. B. Dias, T. L. Blundell

The paper reports the first mycobacterial OtsA structures from M. thermoresistibile, revealing substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate.

bioRxiv · Jul 5, 2019Biochemistry