M. V. B. Dias

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

This study identifies inhibitors of MtbPPAT, a key enzyme in CoA biosynthesis, using fragment linking and CRISPR interference to validate it as a potential anti-TB drug target.

This study uses fragment-based drug discovery to identify novel chemical scaffolds targeting Mycobacterium tuberculosis DHFR, revealing a new binding mode and low micromolar affinity compounds.

The paper reports the first mycobacterial OtsA structures from M. thermoresistibile, revealing substrate preference mechanism and allosteric regulation by 2-oxoglutarate and 2-phosphoglycerate.