Cytoplasmic accumulation of a splice variant of hnRNP A2/B1 contributes to FUS-associated toxicity in a mouse model of ALS
Simona Rossi, Martina Milani, Ilaria Della Valle, S. Bisegna, Valeria Durante, M. Addesse, Erica D’Avorio, Michela Di Salvio, Annalucia Serafino, Gianluca Cestra, Savina Apolloni, Nadia D’Ambrosi, Mauro Cozzolino
This study shows that FUS-induced splicing changes lead to cytoplasmic accumulation of hnRNP A2b/B1 splice variants, promoting stress granule formation and motor neuron toxicity in a mouse model of ALS.
Cell Death and Disease · Mar 29, 2025Peer-reviewedNeuroscience