Molecular BiologyCell Death and DifferentiationPeer-reviewed
DNA damage response defects induced by the formation of TDP-43 and mutant FUS cytoplasmic inclusions and their pharmacological rescue.
Stefania Modafferi, Stefania Farina, Francesca Esposito…·Sofia Francia
This study shows that TDP-43 and FUS cytoplasmic inclusions impair DNA damage response and repair, and that pharmacological stimulation of DDR can rescue these defects in ALS models.