The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding.
C. J. Mycroft-West, D. Su, S. Elli, Y. Li, S. E. Guimond, G. J. Miller, J. E. Turnbull, E. A. Yates, M. Guerrini, D. G. Fernig, M. Andrade de Lima, M. A. Skidmore
The paper shows that SARS-CoV-2 Spike S1 RBD undergoes a conformational change when bound to heparin, suggesting potential for heparin as a therapeutic.
bioRxiv · Feb 29, 2020 · PreprintBiochemistry