Wnt Signalling Orchestrates the Immune Response and Cardiac Damage During Trypanosoma cruzi Infection
X. Volpini, L. F. Ambrosio, A. Brajin, M. B. Brugo, M. P. Aoki, H. W. Rivarola, F. Alfonso, L. Fozzatti, L. Cervi, C. C. Motran
This study shows that inhibiting Wnt signaling during acute T. cruzi infection reduces parasite replication, modulates immune response, and prevents cardiac damage in a mouse model of Chagas disease.
bioRxiv · May 27, 2020Immunology