Inhibition of the SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity
M. Barda-Saad, A. Ben-Shmuel, B. Sabag, G. Biber, A. Puthenveetil, M. Levy, T. Jubany, N. Joseph, O. Matalon, J. Kivelevitz
This study shows that PKC-θ phosphorylates SHP-1, inhibiting its activity and maintaining NK cell activation threshold and cytotoxicity.
bioRxiv · Sep 6, 2021Immunology