Author

A. Ben-Shmuel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

B. Politi· 3 shared H. Achdout· 3 shared H. Levy· 3 shared I. Glinert· 3 shared S. Lazar· 3 shared S. Melamed· 3 shared T. Israely· 3 shared A. Beth-Din· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPharmacology & Toxicology

B. Politi

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer-associated fibroblasts serve as decoys to suppress NK cell anti-cancer cytotoxicity

A. Ben-Shmuel, Y. Gruper, O. Levi-Galibov, H. Rosenberg-Fogler, G. Carradori, Y. Stein, M. Dadiani, M. Naumova, R. Nevo, D. Morzaev-Sulzbach, G. Yagel, S. Mayer, E. Gal-Yam, R. Scherz-Shouval

The paper shows cancer-associated fibroblasts suppress NK cell cytotoxicity by acting as decoys, leading to poor disease outcomes in breast cancer.

bioRxiv · Nov 23, 2023 · PreprintCancer Biology

Inhibition of the SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity

M. Barda-Saad, A. Ben-Shmuel, B. Sabag, G. Biber, A. Puthenveetil, M. Levy, T. Jubany, N. Joseph, O. Matalon, J. Kivelevitz

This study shows that PKC-θ phosphorylates SHP-1, inhibiting its activity and maintaining NK cell activation threshold and cytotoxicity.

bioRxiv · Sep 6, 2021Immunology

Nonclinical Safety and Immunogenicity of an rVSV-ΔG-SARS-CoV-2-S vaccine in mice, hamsters, rabbits and pigs

N. Madar-Balakirski, A. Rosner, S. Melamed, B. Politi, M. Steiner, H. Tamir, Y. Yahalom Ronen, E. Bar-David, A. Ben-Shmuel, A. Sittner, I. Glinert, S. Weiss, E. Bar-Haim, H. Cohen, U. Elia, , H. Marcus

This study evaluates the safety, immunogenicity, and efficacy of an rVSV-ΔG-SARS-CoV-2-S vaccine in multiple animal species, finding no adverse effects and a robust immune response.

bioRxiv · Jul 6, 2021Pharmacology & Toxicology

Mice with Induced Pulmonary Comorbidities Display Severe Lung Inflammation and Mortality following Exposure to SARS-CoV-2

R. Falach, L. Bar-On, S. Lazar, T. Kadar, O. Mazor, M. Aftalion, D. Gur, O. Shifman, O. Israeli, I. Cohen-Gihon, G. Zaide, H. Gutman, Y. Evgy, Y. Vagima, E. Makdasi, , T. Sabo

This study shows that CD-1 mice with induced pulmonary comorbidities develop severe lung inflammation and high mortality after SARS-CoV-2 infection.

bioRxiv · Oct 28, 2020 · PreprintPathology

A single dose of recombinant VSV-{triangleup}G-spike vaccine provides protection against SARS-CoV-2 challenge

Y. Yahalom-Ronen, H. Tamir, S. Melamed, B. Politi, O. Shifman, H. Achdout, E. B. Vitner, O. Israeli, E. Milrot, D. Stein, I. Cohen-Gihon, S. Lazar, H. Gutman, I. Glinert, L. Cherry, , T. Israely

This study develops a recombinant VSV-ΔG-spike vaccine that provides single-dose protection against SARS-CoV-2 in hamsters by inducing neutralizing antibodies and preventing lung pathology.

bioRxiv · Jun 18, 2020Microbiology