Nanchangmycin regulates FYN, FAK and ERK to control the fibrotic activity of hepatic stellate cells
W. Li, J. Y. Chen, C. Sun, R. P. Sparks, L. Pantano, R.-U. Rahman, S. P. Moran, J. V. Pondick, R. Kirchner, D. Wrobel, M. Bieler, S. J. Ho Sui, J. F. Doerner, J. F. Rippmann, A. C. Mullen
This study identifies nanchangmycin as an anti-fibrotic agent that inhibits HSC myofibroblast activity by modulating FYN, FAK, and ERK signaling pathways.
bioRxiv · Oct 8, 2021Cell Biology