Author

R. Kirchner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. C. Mullen· 2 shared C. Sun· 2 shared D. Wrobel· 2 shared J. F. Doerner· 2 shared J. F. Rippmann· 2 shared J. Y. Chen· 2 shared L. Pantano· 2 shared R. P. Sparks· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

A. C. Mullen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

W. Li, R. P. Sparks, C. Sun, Y. Yang, L. Pantano, R. Kirchner, A. Weilheimer, B. J. Toles, J. Y. Chen, S. P. Moran, V. Barrera, Z. Li, P. Zhou, M. L. Brassil, D. Wrobel, , A. C. Mullen

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

bioRxiv · Aug 7, 2023Cell Biology

Quantifying oligomer populations in real time during protein aggregation using single-molecule mass photometry

S. S. Paul, A. Lyons, R. Kirchner, M. T. Woodside

This study uses single-molecule mass photometry to track oligomer populations during protein aggregation, revealing kinetic models and rate constants for tau protein aggregation.

bioRxiv · Jun 15, 2022Biophysics

Nanchangmycin regulates FYN, FAK and ERK to control the fibrotic activity of hepatic stellate cells

W. Li, J. Y. Chen, C. Sun, R. P. Sparks, L. Pantano, R.-U. Rahman, S. P. Moran, J. V. Pondick, R. Kirchner, D. Wrobel, M. Bieler, S. J. Ho Sui, J. F. Doerner, J. F. Rippmann, A. C. Mullen

This study identifies nanchangmycin as an anti-fibrotic agent that inhibits HSC myofibroblast activity by modulating FYN, FAK, and ERK signaling pathways.

bioRxiv · Oct 8, 2021Cell Biology

An siRNA-guided Argonaute protein directs RNA Polymerase V to initiate DNA methylation

M. J. Sigman, K. Panda, R. Kirchner, L. L. McLain, H. Payne, J. R. Peasari, A. Y. Husbands, R. K. Slotkin, A. D. McCue

The paper shows that siRNA-guided ARGONAUTE proteins recruit RNA Polymerase V to initiate DNA methylation without preexisting methylation, challenging previous models of RdDM initiation.

bioRxiv · Aug 19, 2021Plant Biology