Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
N. Meednu, J. Rangel-Moreno, F. Zhang, K. Escalera-Rivera, E. Corsiero, E. Prediletto, E. Dicarlo, S. Goodman, L. Donlin, S. Raychaudhuri, M. Bombardieri, C. Pitzalis, D. Orange, AMP (RA/SLE) netwrok, A. McDavid, J. H. Anolik
The paper identifies NR4A-expressing B cells in RA synovium that show activated transcriptomic profiles and somatic hypermutation, suggesting in situ differentiation and roles in ELS and immune responses.
bioRxiv · May 14, 2021 · PreprintImmunology