J. Rangel-Moreno

SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

Multi-omics Analysis Identifies IgG2b Class-Switching with ALCAM-CD6 Co-Stimulation in Lymph Nodes During Advanced Inflammatory-Erosive Arthritis

The paper identifies ALCAM-CD6 co-stimulation as a pathway promoting IgG2b class-switching in lymph nodes during advanced inflammatory arthritis using spatial and single-cell transcriptomics.

Bi-reporter vaccinia virus for tracking viral infections in vitro and in vivo

This paper introduces bi-reporter vaccinia viruses expressing both fluorescent and luciferase genes to track viral infections in vitro and in vivo, enabling detailed study of infection dynamics and host-pathogen interactions.

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression

The paper identifies NR4A-expressing B cells in RA synovium that show activated transcriptomic profiles and somatic hypermutation, suggesting in situ differentiation and roles in ELS and immune responses.

Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport

This study shows that Cryptococcus neoformans evades pulmonary immunity by modulating xylose precursor transport, leading to altered immune responses and iBALT formation.