S. Raychaudhuri

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

This study identifies dual-specific autophosphorylation in IKK2, showing tyrosine autophosphorylation and ATP-contacting residue K44 regulate substrate specificity for IκBα phosphorylation during NF-κB activation.

Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling

This study shows inflammation-associated fibroblasts disrupt colon epithelial barrier integrity and genome stability via PGE2-EP4 signaling, and EP4 inhibitors can reverse these effects.

The effect of altitude on the expression of immune-related genes in Peruvian rural indigenous

This study identifies altitude-associated immune gene expression differences in Peruvian Andean populations, revealing distinct transcriptomic profiles linked to high-altitude adaptation.

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

This study identifies a phospho-regulated interaction between Dyn1xA and Endophilin A1 via a unique C-terminal extension, essential for ultrafast endocytosis.

The T cell receptor sequence influences the likelihood of T cell memory formation

The study identifies TCR sequence features that influence T cell memory formation and positive selection across different T cell lineages.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases

The paper shows adipocytes regulate fibroblast function through cortisol signaling, and their loss leads to fibroblast dysfunction in inflammatory diseases.

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis

The paper identifies chromatin classes in RA synovial tissue and links them to transcriptional cell states and genetic variants.

L-Ascorbic acid restricts Vibrio cholerae survival in various growth conditions

This study shows that L-ascorbic acid restricts Vibrio cholerae growth across different conditions and biotypes.

Clonal associations of lymphocyte subsets and functional states revealed by single cell antigen receptor profiling of T and B cells in rheumatoid arthritis synovium

This study uses single-cell antigen receptor profiling to identify clonal relationships and functional states of T and B cells in RA synovium.

Combined administration of novobiocin and apomorphine mitigates cholera toxin mediated cellular toxicity

This study identifies apomorphine and novobiocin as effective in reducing cholera toxin A subunit toxicity in yeast and intestinal cells, with combined use showing enhanced efficacy.

Type 2 Inflammation Drives an Airway Basal Stem Cell Program Through Insulin Receptor Substrate Signaling

This study identifies BCAM as a marker of airway basal stem cells and shows that T2 cytokines drive their expansion via IRS signaling in CRSwNP.

Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis

The paper shows that actin filaments and membrane compression from synaptic vesicle exocytosis drive ultrafast endocytosis at synapses.

Gut microbiota modulation in response to combination of Escherichia coli Nissle 1917 and sugars: Lessons from comparative analysis of fecal microbiota of two healthy donors from 2019-2021

The study examines how Escherichia coli Nissle 1917 combined with different sugars affects gut microbiota in two donors over 1.5 years, showing variations in microbial composition based on prebiotics and initial community structure.

Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC

This study uses iterative transcription factor screening to generate microglia-like cells from human iPSCs, identifying a combination of TFs that efficiently differentiate iPSCs into microglia-like cells within 4 days.

Nuclear-injuries by aberrant dynein-forces defeat proteostatic purposes of Lewy Body Inclusions

This study investigates how Lewy Bodies (LBs) and Syn-aggresomes interact in neurons, showing LBs overgrow and cause proteostatic issues through lamina injuries and dynein-force imbalances.

Neutrophil-associated responses to Vibrio cholerae infection in a natural host model

This study investigates the role of calprotectin and metal limitation in inhibiting Vibrio cholerae growth in zebrafish, showing their potential as therapeutic targets.

Repertoire analyses reveal TCR sequence features that influence T cell fate

The paper identifies TCR sequence features that influence T cell fate by analyzing TCR sequences from human cells and developing a scoring system for regulatory potential.

Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression

The paper identifies NR4A-expressing B cells in RA synovium that show activated transcriptomic profiles and somatic hypermutation, suggesting in situ differentiation and roles in ELS and immune responses.

IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease

A comparative study of stress responses elicited by misfolded proteins targeted by bipartite or matrix-targeting signal sequences to yeast mitochondria

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

Multimodal memory T cell profiling identifies a reduction in a polyfunctional Th17 state associated with tuberculosis progression

The paper uses multimodal single-cell profiling to identify a reduction in a polyfunctional Th17-like memory T cell state associated with tuberculosis progression.

Improved Supra-Organization Is A Conformational And Functional Adaptation Of Respiratory Complexes

The paper identifies improved Supra-organization of Respiratory Complexes (iSRC) as a functional adaptation to proteasome inhibition, characterized by subunit integration into oligomers and supercomplexes.

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus Nephritis

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

CUX1 and IκBζ mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts

The paper identifies CUX1 and IκBζ as key mediators of the synergistic inflammatory response to TNF and IL-17A in human synovial fibroblasts, leading to IL-6 production and neutrophil recruitment.

HBEGF+ macrophages identified in rheumatoid arthritis promote joint tissue invasiveness and are reshaped differentially by medications

A newly identified human macrophage phenotype in RA promotes joint tissue invasiveness and shows variable responses to anti-inflammatory medications.

Defining Inflammatory Cell States in Rheumatoid Arthritis Joint Synovial Tissues by Integrating Single-cell Transcriptomics and Mass Cytometry

The paper identifies key inflammatory cell states in RA synovial tissues using integrated single-cell and mass cytometry data from patient samples.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

Cytoplasmic sequestration of the RhoA effector mDiaphanous1 by Prohibitin2 promotes muscle differentiation

The paper shows that Prohibitin2 sequesters mDia1 in the cytoplasm to promote Myogenin expression and muscle differentiation by counteracting mDia1's inhibitory effects in myotubes.