Androgen aggravates aortic aneurysms via suppressing PD-1 in mice
X. Mu, S. Liu, Z. Wang, K. Jiang, T. S. McClintock, A. Stromberg, A. Villasante-Tezanos, E. S. Lee, J. A. Curci, M. C. Gong, Z. Guo
This study shows androgen promotes aortic aneurysms in male mice by suppressing PD-1 in T cells, suggesting immune checkpoint therapy risks for patients with aortic aneurysm risk factors.
bioRxiv · Jan 22, 2023Pathology