Author

M. K. Franklin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Daugherty· 5 shared H. S. Lu· 5 shared H. Sawada· 5 shared D. A. Howatt· 4 shared J. J. Moorleghen· 4 shared Y. Katsumata· 3 shared J. Z. Chen· 2 shared M. Kukida· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersPathology

A. Daugherty

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Author profile →

5 papers

Recent·Most cited

Beta-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Young Mice

M. K. Franklin, H. Sawada, D. A. Howatt, N. Amioka, C.-L. Liang, N. Zhang, D. B. Graf, J. J. Moorleghen, Y. Katsumata, H. S. Lu, A. Daugherty

This study shows that BAPN induces distinct aortic pathologies in the ascending and descending thoracic aortas of young mice, with different structural and cellular changes in each region.

bioRxiv · Oct 22, 2023Pathology

Authentication of In Situ Measurements for Thoracic Aortic Aneurysms in Mice

S. Ohno-Urabe, M. Kukida, M. K. Franklin, Y. Katsumata, W. Su, M. C. Gong, H. S. Lu, A. Daugherty, H. Sawada

The paper develops an in situ method using OCT injection to accurately measure thoracic aortic aneurysms in mice without causing damage.

bioRxiv · Dec 24, 2020Pathology

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1C1041G/+ Mice

J. Z. Chen, H. Sawada, J. J. Moorleghen, M. K. Franklin, D. A. Howatt, M. B. Sheppard, A. E. Mullick, H. S. Lu, A. Daugherty

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

bioRxiv · Jun 1, 2020Physiology

Ultrasound Monitoring of Descending Aortic Aneurysms and Dissections in Mice

H. Sawada, M. K. Franklin, J. J. Moorleghen, D. A. Howatt, M. Kukida, H. S. Lu, A. Daugherty

This study introduces a para-spinal dorsal ultrasound approach to visualize descending aortic regions in mice, overcoming limitations of standard methods.

bioRxiv · Apr 18, 2020Pathology

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies

H. Sawada, Y. Katsumata, H. Higashi, C. Zhang, Y. Li, S. Morgan, L. H. Lee, S. A. Singh, J. Z. Chen, D. A. Howatt, J. J. Moorleghen, M. K. Franklin, D. L. Rateri, Y. H. Shen, S. A. LeMaire, , A. Daugherty

This study shows SHF-derived cells contribute to AngII-induced ascending aortic pathologies through LRP1 and TGF-β signaling, increasing PAI1 expression.

bioRxiv · Feb 2, 2020Pathology