The deacetylase dependent and independent role of HDAC3 in cardiomyopathy
J. Ren, Q. Zeng, H. Wu, X. Liu, M. C. Guida, W. Huang, Y. Zhai, J. Li, R. Bodmer, K. Ocorr, M. Tang
This study investigates the deacetylase-dependent and independent roles of HDAC3 in cardiomyopathy using Drosophila, finding it maintains cardiac contractility and prevents Pericardin deposition independently of its deacetylase activity, but regulates triglyceride homeostasis through this activity.
bioRxiv · Dec 23, 2022Physiology