An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition
M. Nizamoglu, R. H. J. de Hilster, F. Zhao, P. K. Sharma, T. Borghuis, M. C. Harmsen, J. K. Burgess
This study creates an in vitro fibrosis model using crosslinked native ECM hydrogels to alter biomechanics without changing composition, showing increased stiffness and fibroblast myofibroblastic differentiation.
bioRxiv · Feb 2, 2022Pathology