Author

J. K. Burgess

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1

Frequent Co-Authors

T. Borghuis· 4 shared M. Nizamoglu· 3 shared B. N. Melgert· 2 shared W. Timens· 2 shared C. Kirstin Watson· 1 shared C.-A. Brandsma· 1 shared D. A. Knight· 1 shared E. S. White· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersPathology

T. Borghuis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts

M. Nizamoglu, F. Alleblas, T. Koster, T. Borghuis, J. M. Vonk, M. J. Thomas, E. S. White, C. Kirstin Watson, W. Timens, K. C. El Kasmi, B. N. Melgert, I. H. Heijink, J. K. Burgess

This study shows that 3D fibrotic ECM hydrogels alter fibroblast fiber organization and mechanical properties, promoting pro-fibrotic responses.

bioRxiv · Aug 9, 2023Pathology

IL-11 disrupts alveolar epithelial progenitor function

R. K. Kortekaas, K. E. Geillinger-Kaestle, T. Borghuis, K. Belharch, M. Webster, W. Timens, J. K. Burgess, R. Gosens

This study investigates how IL-11 affects alveolar epithelial progenitor function in IPF, finding it disrupts regeneration and suppresses mature cell formation.

bioRxiv · Nov 11, 2022 · PreprintCell Biology

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

K. E. C. Blokland, M. Nizamoglu, H. Habibie, T. Borghuis, M. Schuliga, B. N. Melgert, D. A. Knight, C.-A. Brandsma, S. D. Pouwels, J. K. Burgess

This study shows that fibrotic stiffness activates fibrotic genes and senescence-associated secretory factors in lung fibroblasts, potentially driving disease progression in IPF.

bioRxiv · Sep 27, 2022Cell Biology

An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

M. Nizamoglu, R. H. J. de Hilster, F. Zhao, P. K. Sharma, T. Borghuis, M. C. Harmsen, J. K. Burgess

This study creates an in vitro fibrosis model using crosslinked native ECM hydrogels to alter biomechanics without changing composition, showing increased stiffness and fibroblast myofibroblastic differentiation.

bioRxiv · Feb 2, 2022Pathology