P. K. Sharma

Unravelling Silicon's Transcriptomic Armor in Soybean against Macrophomina phaseolina causing Charcoal Rot Disease

This study uses RNA-Seq to identify genes and pathways involved in soybean resistance to charcoal rot caused by Macrophomina phaseolina, showing that potassium silicate reduces disease incidence.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

An in vitro model of fibrosis using crosslinked native extracellular matrix-derived hydrogels to modulate biomechanics without changing composition

This study creates an in vitro fibrosis model using crosslinked native ECM hydrogels to alter biomechanics without changing composition, showing increased stiffness and fibroblast myofibroblastic differentiation.

Computational and biochemical analyses reveal that cofilin-2 self assembles into amyloid-like structures and promotes the aggregation of other proteinaceous species: Pathogenic relevance to myopathies

This study shows cofilin-2 can form amyloid-like structures and promote protein aggregation, suggesting a role in myopathies.

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8+ T cell clone size and cytotoxicity

The paper uses single-cell and bulk RNA sequencing to show that CD8+ T cell subset and clone size influence gene expression responses to immune checkpoint blockade, and that pre-treatment cytotoxicity and clonality predict progression-free survival.