Author

M. C. Major

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:deep learning· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. M. Edgar· 3 shared P. W. Zandstra· 3 shared C. Zimmerman· 2 shared E. L. Castle· 2 shared M. I. Ibanez-Rios· 2 shared Y. S. Michaels· 2 shared A. Forrow· 1 shared A. Hagner· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersImmunology

J. M. Edgar

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

Y. S. Michaels, M. C. Major, B. Bonham-Carter, J. Zhang, T. Heydari, J. M. Edgar, L. Greenstreet, R. Vilarrasa-Blasi, S. Kim, E. L. Castle, A. Forrow, M. I. Ibanez-Rios, C. Zimmerman, Y. Chung, T. Stach, , P. W. Zandstra

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

bioRxiv · Oct 6, 2023 · PreprintImmunology

Sex biased human thymic architecture guides T cell development through spatially defined niches

L. N. Stankiewicz, F. M. Rossi, P. W. Zandstra, K. Salim, E. A. Flaschner, Y. X. Wang, J. M. Edgar, B. Z. Lin, G. C. Bingham, M. C. Major, R. D. Jones, H. Blau, E. Rideout, M. K. Levings

The paper maps sex differences in thymic niches using spatial multi-omics to reveal how sex influences T cell development and immune function.

bioRxiv · Apr 13, 2023Immunology

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

Y. S. Michaels, J. M. Edgar, M. C. Major, E. L. Castle, C. Zimmerman, T. Yin, A. Hagner, C. Lau, M. I. Ibanez-Rios, D. J. H. F. Knapp, P. W. Zandstra

This study identifies DLL4 and VCAM1 as critical factors enhancing T cell progenitor emergence from human pluripotent stem cells during the endothelial-to-hematopoietic transition.

bioRxiv · Nov 26, 2021Bioengineering