Author

Y. S. Michaels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

C. Zimmerman· 2 shared D. J. Knapp· 2 shared E. L. Castle· 2 shared J. M. Edgar· 2 shared M. C. Major· 2 shared M. I. Ibanez-Rios· 2 shared P. W. Zandstra· 2 shared T. A. Fulga· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

C. Zimmerman

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Time- and lineage-resolved transcriptional profiling uncovers gene expression programs and clonal relationships that underlie human T lineage specification

Y. S. Michaels, M. C. Major, B. Bonham-Carter, J. Zhang, T. Heydari, J. M. Edgar, L. Greenstreet, R. Vilarrasa-Blasi, S. Kim, E. L. Castle, A. Forrow, M. I. Ibanez-Rios, C. Zimmerman, Y. Chung, T. Stach, , P. W. Zandstra

This study uses time-resolved single-cell RNA sequencing to uncover gene expression programs and clonal relationships during human T lineage specification.

bioRxiv · Oct 6, 2023 · PreprintImmunology

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

Y. S. Michaels, J. M. Edgar, M. C. Major, E. L. Castle, C. Zimmerman, T. Yin, A. Hagner, C. Lau, M. I. Ibanez-Rios, D. J. H. F. Knapp, P. W. Zandstra

This study identifies DLL4 and VCAM1 as critical factors enhancing T cell progenitor emergence from human pluripotent stem cells during the endothelial-to-hematopoietic transition.

bioRxiv · Nov 26, 2021Bioengineering

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

M. B. Barnkob, Y. S. Michaels, V. Andre, P. S. Macklin, U. Gileadi, S. Valvo, M. Rei, C. Kulicke, J.-L. Chen, V. Jain, V. Woodcock, H. Colin-York, A. V. Hadjinicolaou, Y. Kong, V. Mayya, , V. Cerundolo

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

bioRxiv · Nov 20, 2019Immunology

Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression

D. J. Knapp, Y. S. Michaels, M. Jamilly, Q. R. Ferry, H. Barbosa, T. A. Milne, T. A. Fulga

The paper identifies sequence determinants of tRNA promoter and processing activities to engineer a Pol-II promoter for specific guide RNA expression.

bioRxiv · Jun 8, 2018Bioengineering