T. Yin

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

Electron microscopic analysis of the influence of iPSC-derived motor neurons on bioengineered human skeletal muscle tissues

The paper examines how iPSC-derived motor neurons affect the ultrastructure of bioengineered human skeletal muscle tissues, showing improved sarcomere organization with motor neuron co-culture.

Phylogenomics reveals patterns of ancient hybridization and differential diversification contributing to phylogenetic conflict in Populus L. and Salix L.

This study uses phylogenomic analysis to identify ancient hybridization and differential diversification as sources of phylogenetic conflict in Populus and Salix.

Single-nuclei transcriptomics of dog hippocampus reveals the distinct cellular mechanism of domestication

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells

This study identifies DLL4 and VCAM1 as critical factors enhancing T cell progenitor emergence from human pluripotent stem cells during the endothelial-to-hematopoietic transition.

Two antagonistic effect genes mediate separation of sexes in a fully dioecious plant

The paper identifies two genes in Populus deltoides that antagonistically regulate sex determination by repressing female structures and promoting male structures through epigenetic and RNA-based mechanisms.

Targeting USP9x/SOX2 axis contributes to the anti-osteosarcoma effect of neogambogic acid

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

Palmitoylation of the oncogenic RhoGEF TGAT is dispensable for membrane localization and consequent activation of RhoA

This study shows that membrane association of TGAT is critical for its activity, but palmitoylation is not required for membrane localization or RhoA activation.