Identification of a critical horseshoe-shaped region in the nsp5 (Mpro, 3CLpro) protease interdomain loop (IDL) of coronavirus mouse hepatitis virus (MHV)
B. C. Nick, M. C. Pandya, X. Lu, M. E. Franke, S. M. Callahan, E. F. Hasik, S. T. Berthrong, M. R. Denison, C. C. Stobart
This study identifies a conserved horseshoe-shaped region in the nsp5 protease interdomain loop of MHV that is essential for viral replication and may serve as a new drug target.
bioRxiv · Jun 18, 2020 · PreprintMicrobiology