Author

M. R. Denison

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

X. Lu· 7 shared A. J. Pruijssers· 3 shared J. Gribble· 3 shared L. J. Stevens· 3 shared M. L. Agostini· 3 shared N. R. Sexton· 3 shared A. S. George· 2 shared D. P. Porter· 2 shared

Activity by Year

2017-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

X. Lu

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Author profile →

8 papers

Recent·Most cited

Distinct genetic determinants and mechanisms of SARS-CoV-2 resistance to remdesivir

L. J. Stevens, A. J. Pruijssers, H. W. Lee, C. J. Gordon, E. P. Tchesnokov, J. Gribble, A. S. George, T. M. Hughes, X. Lu, J. Li, J. K. Perry, D. P. Porter, T. Cihlar, T. P. Sheahan, R. S. Baric, , M. R. Denison

This study identifies distinct mutations in SARS-CoV-2's RdRp that confer remdesivir resistance, showing their biochemical mechanisms and transferability to other coronaviruses.

bioRxiv · Jan 25, 2022 · PreprintMicrobiology

Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage

S. C. Smith, J. Gribble, J. R. Diller, M. A. Wiebe, T. W. Thoner, M. R. Denison, K. M. Ogden

This study shows reovirus generates internally deleted defective genome segments through sequence-directed recombination during passage, while rotavirus rarely does so.

bioRxiv · Oct 19, 2020Microbiology

Identification of a critical horseshoe-shaped region in the nsp5 (Mpro, 3CLpro) protease interdomain loop (IDL) of coronavirus mouse hepatitis virus (MHV)

B. C. Nick, M. C. Pandya, X. Lu, M. E. Franke, S. M. Callahan, E. F. Hasik, S. T. Berthrong, M. R. Denison, C. C. Stobart

This study identifies a conserved horseshoe-shaped region in the nsp5 protease interdomain loop of MHV that is essential for viral replication and may serve as a new drug target.

bioRxiv · Jun 18, 2020 · PreprintMicrobiology

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

A. J. Pruijssers, A. S. George, A. Schäfer, S. R. Leist, L. E. Gralinski, K. H. Dinnon, B. L. Yount, M. L. Agostini, L. J. Stevens, J. D. Chappell, X. Lu, T. M. Hughes, K. L. Gully, D. R. Martinez, A. J. Brown, , T. P. Sheahan

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

bioRxiv · Apr 27, 2020Microbiology

The coronavirus proofreading exoribonuclease mediates extensive viral recombination

J. Gribble, A. J. Pruijssers, M. L. Agostini, J. Anderson-Daniels, J. D. Chappell, X. Lu, L. J. Stevens, A. L. Routh, M. R. Denison

This study shows that the coronavirus proofreading exoribonuclease nsp14-ExoN is essential for RNA recombination and generates defective viral genomes.

bioRxiv · Apr 23, 2020Microbiology

Fitness barriers limit reversion of a proofreading-deficient coronavirus

K. W. Graepel, M. L. Agostini, X. Lu, N. R. Sexton, M. R. Denison

This study shows that reversion of a proofreading-deficient coronavirus (ExoN-AA) is hindered by fitness barriers, as compensatory mutations outside the ExoN motif I are more advantageous than partial reversion.

bioRxiv · Apr 26, 2019Microbiology

Mouse hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunity

J. B. Case, Y. Li, R. Elliott, X. Lu, K. W. Graepel, N. R. Sexton, E. C. Smith, S. R. Weiss, M. R. Denison

This study shows that MHV nsp14 exoribonuclease activity is necessary for resisting innate immunity by affecting viral RNA and modifications.

bioRxiv · Aug 29, 2017Microbiology

Proofreading-deficient coronaviruses adapt over long-term passage for increased fidelity and fitness without reversion of exoribonuclease-inactivating mutations

K. Graepel, X. Lu, J. B. Case, N. R. Sexton, E. C. Smith, M. R. Denison

bioRxiv · Aug 11, 2017Microbiology