Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate
L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick
This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.
bioRxiv · Feb 24, 2021 · PreprintCell Biology