Author

O. I. Gan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

J. E. Dick· 4 shared A. Murison· 3 shared E. R. Lechman· 3 shared E. Wagenblast· 3 shared G. Krivdova· 3 shared J. L. McLeod· 3 shared A. G. X. Zeng· 2 shared J. A. Kennedy· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

J. E. Dick

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Author profile →

4 papers

Recent·Most cited

KDM6A loss sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition

L. D. Boila, S. Ghosh, S. K. Bandyopadhyay, L. Jin, A. Murison, A. G. X. Zeng, W. Shaikh, S. Bhowmik, S. S. N. A. Muddineni, M. Biswas, S. Sinha, S. S. Chatterjee, N. Mbong, O. I. Gan, A. Bose, , A. Sengupta

This study shows that KDM6A loss in AML increases sensitivity to PARP and BCL2 inhibitors, suggesting a new combination therapy approach for KDM6A-mutant AML.

bioRxiv · Jul 12, 2022 · PreprintCancer Biology

Identification of the Global miR-130a Targetome Reveals a Novel Role for TBL1XR1 in Hematopoietic Stem Cell Self-Renewal and t(8;21) AML

G. Krivdova, V. Voisin, E. M. Schoof, S. A. Marhon, A. J. Murison, J. L. McLeod, M. Gabra, A. G. Zeng, E. L. Van Nostrand, S. J. Aigner, A. A. Shishkin, B. A. Yee, K. G. Hermans, A. G. Trotman-Grant, N. Mbong, , E. R. Lechman

This study identifies miR-130a as a regulator of HSC self-renewal and differentiation, with TBL1XR1 as a key target, and shows its role in maintaining the oncogenic program in t(8;21) AML.

bioRxiv · Jul 30, 2021Cell Biology

Dichotomous regulation of lysosomes by MYC and TFEB controls hematopoietic stem cell fate

L. Garcia-Prat, K. B. Kaufmann, F. Schneiter, V. Voisin, A. Murison, J. Chen, M. Chan-Seng-Yue, O. I. Gan, J. L. McLeod, S. A. Smith, M. C. Shoong, D. Parris, K. Pan, A. G. X. Zeng, G. Krivdova, , J. E. Dick

This study shows that lysosomes are regulated by TFEB and MYC to balance catabolic and anabolic processes in hematopoietic stem cells, influencing their fate and activation.

bioRxiv · Feb 24, 2021 · PreprintCell Biology

Mapping the Cellular Origin and Early Evolution of Leukemia in Down Syndrome

E. Wagenblast, J. Araujo, O. I. Gan, S. K. Cutting, A. Murison, G. Krivdova, M. Azkanaz, J. L. McLeod, S. A. Smith, S. A. Marhon, M. Gabra, M. Chan-Seng-Yue, L. Garcia-Prat, L. Salmena, D. D. D. De Carvalho, , E. R. Lechman

This study identifies the cellular origin and mechanisms of leukemia predisposition in Down syndrome by analyzing gene mutations and their effects in fetal hematopoietic cells.

bioRxiv · Nov 29, 2020Cancer Biology