M. C. van Zelm

Bivalent COVID-19 vaccines boost the capacity of pre-existing SARS-CoV-2-specific memory B cells to cross-recognize Omicron subvariants

Third dose COVID-19 mRNA vaccine enhances IgG4 isotype switching and recognition of Omicron subvariants by memory B cells after mRNA but not adenovirus priming

This study shows that a third mRNA COVID-19 vaccine dose increases IgG4+ memory B cells and Omicron subvariant recognition, but only in those primed with mRNA, not adenovirus.

Accurate determination of house dust mite sensitization in asthma and allergic rhinitis through cytometric detection of Der p 1 and Der p 2 binding on Basophils (CytoBas)

This paper introduces the CytoBas assay, a flow cytometry method using fluorescent allergen tetramers to detect HDM sensitization in basophils, showing high sensitivity and specificity for Der p 1 and Der p 2.

COVID-19 adenoviral vector vaccination elicits a robust memory B cell response with the capacity to recognize Omicron BA.2 and BA.5 variants

This study compares memory B cell responses to ChAdOx1 and BNT162b2 vaccines, showing ChAdOx1 generates Bmem recognizing Omicron variants BA.2 and BA.5.

Double-dose mRNA vaccination to SARS-CoV-2 progressively increases recognition of variants-of-concern by Spike RBD-specific memory B cells

This study shows that a second dose of BNT162b2 vaccine increases the number and variant recognition ability of RBD-specific memory B cells.

Absence of surface IgD does not impair naive B cell homeostasis and memory B cell formation in humans

The paper shows that human B cells lacking surface IgD develop normally and form memory B cells without impairment.