R. D. de Vries

The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

This study shows that endothelial cells are abortively infected by influenza A virus and contribute to systemic inflammation through increased cytokine secretion in co-cultures with infected epithelial cells.

Pulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters

This study inoculates Syrian golden hamsters with SARS-CoV-2 Omicron BA.1 to compare its pathogenicity and viral shedding to Delta, finding reduced clinical signs and viral shedding but still pneumonia, with pre-existing immunity offering protection.

Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.

Sustained replication of synthetic canine distemper virus defective genomes in vitro and in vivo

This paper generates and characterizes defective interfering genomes of canine distemper virus, showing their sustained replication in vivo and potential as therapeutic agents.

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

Measles skin rash: infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to keratinocytes in the epidermis

This study investigates measles skin rash pathogenesis, showing that viral infection of dermal lymphoid and myeloid cells precedes dissemination to epidermal keratinocytes, with nectin-4 dependency for keratinocyte infection.

Identification and characterization of CD4+ T cell epitopes after Shingrix vaccination.

This study identifies and characterizes CD4+ T cell epitopes specific to Shingrix vaccination, showing a shift in immunodominance from non-structural proteins to gE and mapping HLA restrictions for these epitopes.