Grape-seed proanthocyanidin extract (GSPE) modulates diurnal oscillations of key hepatic metabolic genes and metabolites alleviating hepatic lipid deposition in cafeteria-fed obese rats in a time-of-day-dependent manner
R. M. Rodriguez, L. V. de Assis, M. Colom-Pellicer, S. Quesada-Vazquez, A. Cruz-Carrion, X. Escote, H. Oster, G. Aragones, M. Mulero
This study shows that GSPE reduces hepatic lipid deposition in obese rats by modulating diurnal rhythms of metabolic genes and metabolites, depending on the time of administration.
bioRxiv · Jul 20, 2022 · PreprintPharmacology & Toxicology