Author

L. V. de Assis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Organism:mouse· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. Oster· 5 shared J. Mittag· 3 shared L. Harder· 3 shared I. Cascorbi· 2 shared I. Nagel· 2 shared J. T. Lacerda· 2 shared M. Kaehler· 2 shared O. Rawashdeh· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersPhysiology

H. Oster

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5 papers

Recent·Most cited

Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice

L. V. de Assis, L. Harder, J. Inderhees, O. Johren, J. Mittag, H. Oster

This study investigates how THRB affects diurnal hepatic lipid metabolism in adult male mice, finding THRB deficiency disrupts metabolic rhythms and promotes steatosis.

bioRxiv · Jan 30, 2024Physiology

Tuning of liver circadian transcriptome rhythms by thyroid hormone state in male mice

L. V. de Assis, L. Harder, J. T. Lacerda, R. Parsons, M. Kaehler, I. Cascorbi, I. Nagel, O. Rawashdeh, J. Mittag, H. Oster

This study investigates how thyroid hormone levels affect liver circadian transcriptome rhythms in mice, identifying 516 genes as molecular markers of liver TH state.

bioRxiv · Sep 23, 2023Physiology

Non-alcoholic steatohepatitis disrupts diurnal liver transcriptome rhythms in mice

L. V. de Assis, M. Demir, H. Oster

This study shows that NASH disrupts diurnal liver transcriptome rhythms in mice, with phase and amplitude changes in metabolic and DNA repair pathways, and improves DEG detection by accounting for circadian rhythms.

bioRxiv · Jan 24, 2023 · PreprintPhysiology

Grape-seed proanthocyanidin extract (GSPE) modulates diurnal oscillations of key hepatic metabolic genes and metabolites alleviating hepatic lipid deposition in cafeteria-fed obese rats in a time-of-day-dependent manner

R. M. Rodriguez, L. V. de Assis, M. Colom-Pellicer, S. Quesada-Vazquez, A. Cruz-Carrion, X. Escote, H. Oster, G. Aragones, M. Mulero

This study shows that GSPE reduces hepatic lipid deposition in obese rats by modulating diurnal rhythms of metabolic genes and metabolites, depending on the time of administration.

bioRxiv · Jul 20, 2022 · PreprintPharmacology & Toxicology

Rewiring of liver diurnal transcriptome rhythms by triiodothyronine (T3) supplementation

L. V. de Assis, L. Harder, J. T. Lacerda, R. Parsons, M. Kaehler, I. Cascorbi, I. Nagel, O. Rawashdeh, J. Mittag, H. Oster

This study shows that T3 supplementation reorganizes liver transcriptome rhythms, affecting metabolic processes independently of local circadian clocks.

bioRxiv · Apr 28, 2022Physiology