Fusion of a functional glutaredoxin to the radical-generating subunit of ribonucleotide reductase
I. Rozman Grinberg, D. Lundin, M. Sahlin, M. Crona, G. Berggren, A. Hofer, B.-M. Sjöberg
This paper demonstrates that a fused glutaredoxin domain in F. ignava NrdB functions as a reductant for RNR via both dithiol and monothiol mechanisms, and shows the ATP-cone's role in regulating enzyme activity through dATP binding.
bioRxiv · Jul 20, 2018 · PreprintBiochemistry