Tau amyloidogenesis begins with a loss of its conformational polymorphism
M. d. C. Fernandez-Ramirez, R. Hervas, M. Menendez, D. V. Laurents, M. Carrion-Vazquez
This study uses AFM-SMFS to show that tau aggregation is associated with reduced conformational polymorphism, driven by mutations and chemical conditions.
bioRxiv · Jun 18, 2020 · PreprintBiophysics