D. V. Laurents

Architectonic Principles of Polyproline II Bundle Protein Domains

The paper analyzes glycine-rich polyproline II helix assemblies to identify common structural features that could aid in protein design.

Insight into Polyproline II Helical Bundle Stability and Folding from NMR Spectroscopic Characterization of the Snow Flea Antifreeze Protein Denatured State

This study uses NMR spectroscopy to analyze the denatured state of snow flea antifreeze protein, revealing conformational entropy and structural insights into PPII helical bundle stability.

Fused in Sarcoma undergoes cold denaturation: implications on phase separation

This study shows that FUS globular domains undergo cold denaturation, promoting phase separation under cold stress conditions.

SARS-CoV-2 Nsp8 N-terminal domain dimerizes and harbors autonomously folded elements

This study shows that the SARS-CoV-2 Nsp8 N-terminal domain dimerizes and contains both folded and disordered regions.

Towards Targeting the Disordered SARS-CoV-2 Nsp2 C-terminal Region: Partial Structure and Dampened Mobility Revealed by NMR Spectroscopy

The paper uses NMR spectroscopy to study the disordered C-terminal region of SARS-CoV-2 Nsp2, revealing partial structure and dynamic behavior.

Glycine Rich Segments Adopt Polyproline II Helices Which May Contribute to Biomolecular Condensate Formation

The paper investigates whether Gly-rich segments of disordered proteins form polyproline II helices, which may contribute to biomolecular condensate stability.

Tau amyloidogenesis begins with a loss of its conformational polymorphism

This study uses AFM-SMFS to show that tau aggregation is associated with reduced conformational polymorphism, driven by mutations and chemical conditions.

Preferred Conformations in the Intrinsically Disordered Region of Human CPEB3, a Functional Amyloid Linked to Memory Consolidation

This study identifies preferred conformations in the intrinsically disordered region of human CPEB3 using NMR spectroscopy, revealing structural motifs and potential functional interactions related to memory consolidation.

Phe-Gly Motifs Drive Fibrillization of TDP-43's Prion-Like Domain Droplets

The paper shows Phe-Gly motifs drive fibrillization from TDP-43 droplets, revealing structural differences between droplets and fibrils.

Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization

The paper investigates cohesin-dockerin interactions in cellulosomes, revealing two binding modes and an allosteric regulation mechanism via proline isomerization.