Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells
D. Neumeier, A. Yermanos, A. Agrafiotis, L. Csepregi, T. Chowdhury, R. A. Ehling, R. Kuhn, R. Brisset-Di Roberto, M. Di Tacchio, R. Antonialli, D. Starkie, D. J. Lightwood, A. Oxenius, S. T. Reddy
This study investigates whether clonal expansion of plasma cells is deterministic or stochastic by analyzing antigen-specificity, affinity, and epitope convergence in antibody repertoires.
bioRxiv · Jul 16, 2021Immunology