Author

R. A. Ehling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2

Frequent Co-Authors

S. T. Reddy· 8 shared A. Yermanos· 4 shared B. Murrell· 4 shared D. J. Sheward· 4 shared C. Kim· 3 shared G. B. Karlsson Hedestam· 3 shared J. Albert· 3 shared A. Agrafiotis· 2 shared

Activity by Year

2019-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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8 shared papersImmunology

S. T. Reddy

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Author profile →

8 papers

Recent·Most cited

Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies

D. J. Sheward, C. Kim, J. Fischbach, S. Muschiol, R. A. Ehling, N. K. Björkström, G. B. Karlsson Hedestam, S. T. Reddy, J. Albert, T. P. Peacock, B. Murrell

The paper evaluates neutralisation resistance of Omicron sublineages BA.2.75.2, BA.4.6, and BA.2.10.4, finding BA.2.75.2 shows extensive escape from neutralising antibodies.

bioRxiv · Sep 16, 2022Immunology

Evasion of neutralizing antibodies by Omicron sublineage BA.2.75

D. J. Sheward, C. Kim, J. Fischbach, S. Muschiol, R. A. Ehling, N. K. Björkström, G. B. Karlsson Hedestam, S. T. Reddy, J. Albert, T. P. Peacock, B. Murrell

This study evaluates the neutralization sensitivity of the SARS-CoV-2 BA.2.75 sublineage to monoclonal antibodies and sera from individuals infected with earlier variants.

bioRxiv · Jul 19, 2022 · PreprintImmunology

Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron)

D. J. Sheward, C. Kim, R. A. Ehling, A. Pankow, X. Castro Dopico, D. P. Martin, S. T. Reddy, J. Dillner, G. B. Karlsson Hedestam, J. Albert, B. Murrell

This study assesses neutralizing antibody responses against the SARS-CoV-2 Omicron variant, showing reduced potency compared to the pandemic founder but with some cross-neutralizing capacity in vaccinated individuals.

bioRxiv · Dec 19, 2021 · PreprintImmunology

Generation of a single-cell B cell atlas of antibody repertoires and transcriptomes to identify signatures associated with antigen-specificity

A. Agrafiotis, D. Neumeier, K.-L. Hong, T. Chowdhury, R. A. Ehling, R. Kuhn, I. Sandu, V. Kreiner, T.-S. Cotet, D. Laslo, S. Anzböck, D. Starkie, D. J. Lightwood, A. Oxenius, S. T. Reddy, A. Yermanos

The paper generates a single-cell B cell atlas to link antibody repertoires, transcriptomes, and antigen specificity in murine immunization models.

bioRxiv · Nov 9, 2021Immunology

Phenotypic determinism and stochasticity in antibody repertoires of clonally expanded plasma cells

D. Neumeier, A. Yermanos, A. Agrafiotis, L. Csepregi, T. Chowdhury, R. A. Ehling, R. Kuhn, R. Brisset-Di Roberto, M. Di Tacchio, R. Antonialli, D. Starkie, D. J. Lightwood, A. Oxenius, S. T. Reddy

This study investigates whether clonal expansion of plasma cells is deterministic or stochastic by analyzing antigen-specificity, affinity, and epitope convergence in antibody repertoires.

bioRxiv · Jul 16, 2021Immunology

A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients

F. Bieberich, R. Vazquez-Lombardi, A. Yermanos, R. A. Ehling, D. M. Mason, B. Wagner, E. Kapetanovic, R. B. Di Roberto, C. R. Weber, M. Savic, F. Rudolf, S. T. Reddy

This study uses single-cell sequencing to analyze immune repertoires and transcriptomes in convalescent COVID-19 patients, revealing age-related differences in T and B cell responses.

bioRxiv · Feb 12, 2021Immunology

Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2

R. A. Ehling, C. R. Weber, D. M. Mason, S. Friedensohn, B. Wagner, F. Bieberich, E. Kapetanovic, R. Vazquez-Lombardi, R. B. Di Roberto, K.-L. Hong, C. Wagner, D. J. Sheward, B. Murrell, A. Yermanos, A. Cuny, , S. T. Reddy

Single-cell sequencing and screening identify expanded plasma cell clones in COVID-19 patients producing SARS-CoV-2-specific neutralizing antibodies.

bioRxiv · Feb 12, 2021 · PreprintImmunology

Molecular design, optimization and genomic integration of chimeric B cell receptors in murine B cells

T. Pesch, L. Bonati, W. Kelton, C. Parola, R. A. Ehling, L. Csepregi, D. Kitamura, S. T. Reddy

The paper designs, optimizes, and genomically integrates chimeric B cell receptors (CBCRs) in murine B cells using CRISPR-Cas9, demonstrating robust surface expression and antigen recognition.

bioRxiv · Jun 5, 2019Immunology