The Plasmodium falciparum protein VCAP1 controls Maurer’s cleft morphology, knob architecture and PfEMP1 trafficking
E. McHugh, O. Carmo, A. Blanch, O. Looker, B. Liu, S. Tiash, S. Batinovic, A. Low J.Y, P. McMillan, L. Tilley, M. Dixon
This study identifies VCAP1 as a key protein controlling Maurer’s cleft structure and PfEMP1 trafficking in Plasmodium falciparum, leading to altered parasite growth and RBC deformability.
bioRxiv · Aug 20, 2019Microbiology