G. Burgio

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

GBP1 promotes killing of multidrug-resistant Acinetobacter baumannii and promotes host protection via interferon signalling and inflammasome activation.

This study shows GBP1 and interferon signaling enhance host defense against multidrug-resistant A. baumannii by promoting inflammasome activation and killing resistant bacteria.

Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

This study compares the activation of the NLRP3 inflammasome and programmed cell death by different Acinetobacter baumannii strains in macrophages and mice, revealing strain-specific differences in virulence and immune response.

Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain

This study investigates the role of helix 1 and the bridge helix in the allosteric activation of FnCas12a by showing their coordinated movement is essential for lid opening and DNA cleavage.

Nuclear stabilisation of p53 requires a functional nucleolar surveillance pathway

This study identifies the nucleolar surveillance pathway (NSP) as a central regulator of p53 stability, showing its role in integrating various cellular stresses and its potential as a therapeutic target in cancer.

Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

This study replaces the amide group in pantothenamides with heteroaromatic rings to improve antiplasmodial activity against Plasmodium species.

Host porphobilinogen deaminase deficiency confers malaria resistance in Plasmodium chabaudi but not in Plasmodium falciparum or Plasmodium berghei during intraerythrocytic growth

This study identifies a host mutation in porphobilinogen deaminase (PBGD) that confers resistance to Plasmodium chabaudi but not other Plasmodium species during blood-stage infection.

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria.

This study shows that KCC1 activation protects mice from experimental cerebral malaria by increasing CD4+ T cells and TNF- response.

Ankyrin-1 gene exhibits allelic heterogeneity in conferring protection against malaria

This study identifies two Ank-1 mutations in mice that confer differing protection against Plasmodium chabaudi infections, demonstrating allelic heterogeneity in ankyrin-1's role in malaria resistance.