Liver Receptor Homolog-1 (LRH-1/NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
R. Lambrecht, M. E. Delgado, V. Gloe, K. Schuetz, A. P. Plazzo, B. Franke, T. S. Phan, J. R. Fleming, O. Mayans, T. Brunner
This study shows that LRH-1 deletion protects mice from TNF-induced liver damage by inhibiting NF-B activity and promoting BIM degradation.
bioRxiv · May 24, 2023Cell Biology