Author

M. E. Hurley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

E. White· 3 shared I. Jayasinghe· 3 shared T. M. D. Sheard· 3 shared D. Steele· 2 shared A. J. Smith· 1 shared E. Pervolaraki· 1 shared H. M. Kirton· 1 shared J. Colyer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiophysics

E. White

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3 papers

Recent·Most cited

Correlative super-resolution analysis of cardiac calcium sparks and their molecular origins in health and disease

M. E. Hurley, E. White, T. M. D. Sheard, D. Steele, I. Jayasinghe

The paper correlates cardiac calcium sparks with RyR clustering patterns using super-resolution microscopy in healthy and failing rat ventricular myocytes, revealing a link between spark properties and RyR organization.

bioRxiv · Feb 12, 2023 · PreprintBiophysics

3D visualisation of the cardiac ryanodine receptor clusters and the molecular-scale fraying of dyads

T. M. D. Sheard, M. E. Hurley, A. J. Smith, J. Colyer, E. White, I. Jayasinghe

This study uses 3D visualization to examine RyR cluster structure and JPH2 sub-domains in cardiac dyads, revealing fragmentation in disease states.

bioRxiv · Oct 21, 2021 · PreprintBiophysics

A super-resolution protocol to correlate structural underpinnings of fast second-messenger signalling in primary cell types

M. E. Hurley, T. M. D. Sheard, R. Norman, H. M. Kirton, S. S. Shah, E. Pervolaraki, Z. Yang, N. Gamper, E. White, D. Steele, I. Jayasinghe

The paper describes a correlative imaging protocol to visualize calcium signals and ryanodine receptors at nanoscale resolution in primary cells.

bioRxiv · Sep 29, 2020Biophysics