CIC-DUX4 expression drives the development of small round cell sarcoma in transgenic zebrafish: a new model revealing a role for ETV4 in CIC-mediated sarcomagenesis
S. Watson, G. C. Kendall, D. Rakheja, M. E. McFaul, B. W. Draper, F. Tirode, O. Delattre, J. F. Amatruda
This study establishes a zebrafish model of CIC-DUX4 sarcoma, showing that CIC-DUX4 drives tumor development and that Etv4 is critical for its oncogenic effects.
bioRxiv · Jan 12, 2019 · PreprintCancer Biology