O. Delattre

Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell lines

This study compares genomic and phenotypic stability of pediatric Ewing sarcoma cell lines to adult carcinoma cell lines over 12 months of culture.

Simple droplet microfluidics platform for drug screening on cancer spheroids

This paper presents a microfluidics platform for drug screening on cancer spheroids, reducing cell requirements and enabling sequential drug exposure.

Chimeric protein EWS-FLI1 drives cell proliferation in Ewing Sarcoma via overexpression of KCNN1.

This study identifies KCNN1 as a target of EWS-FLI1 and EWS-ERG fusion proteins in Ewing Sarcoma, showing its role in cell proliferation and potential as a therapeutic target.

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis

This study identifies VGLL2-NCOA2 as an oncogene driving pediatric sarcomagenesis by reactivating developmental programs, with ARF6 overexpression as a potential therapeutic target.

Automated compound testing in zebrafish xenografts identifies combined MCL-1 and BCL-XL inhibition to be effective against Ewing sarcoma

Interplay between intrinsic reprogramming potential and microenvironment controls neuroblastoma cell plasticity and identity

This study shows that neuroblastoma cells can switch between noradrenergic and mesenchymal identities through epigenetic reprogramming, influenced by both intrinsic factors and the microenvironment.

Exosomes transmit retroelement RNAs to drive inflammation and immunosuppression in Ewing Sarcoma

This study identifies retroelement RNAs in Ewing Sarcoma exosomes that induce inflammation and immunosuppression in recipient cells.

Cooperation of dominant oncogenes with regulatory germline variants shapes clinical outcomes in childhood cancer

This study shows how a dominant oncogene and regulatory germline variants together influence tumor growth, survival, and drug response in Ewing sarcoma.

Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single cell resolution

This study identifies transcriptional programs driving intratumoral heterogeneity in Ewing sarcoma using single-cell RNA-sequencing and chromatin analysis.

CIC-DUX4 expression drives the development of small round cell sarcoma in transgenic zebrafish: a new model revealing a role for ETV4 in CIC-mediated sarcomagenesis

This study establishes a zebrafish model of CIC-DUX4 sarcoma, showing that CIC-DUX4 drives tumor development and that Etv4 is critical for its oncogenic effects.