Author

J. F. Amatruda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:zebrafish· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Marchetto· 1 shared B. W. Draper· 1 shared C. Arrigoni· 1 shared D. Rakheja· 1 shared D. Saucier· 1 shared E. Vasileva· 1 shared F. Cidre-Aranaz· 1 shared F. S. Wehweck· 1 shared

Activity by Year

2019-2021 · peak 2/yr

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10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Marchetto

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3 papers

Recent·Most cited

Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

E. Vasileva, M. Warren, T. J. Triche, J. F. Amatruda

This study develops a zebrafish model of Ewing sarcoma and identifies heparan sulfate proteoglycan metabolism as a driver of tumor growth, showing that targeting this pathway reduces tumorigenicity.

bioRxiv · May 25, 2021Cancer Biology

Oncogenic hijacking of a developmental transcription factor evokes therapeutic vulnerability for ROS-induction in Ewing sarcoma

A. Marchetto, S. Ohmura, M. F. Orth, J. Li, F. S. Wehweck, M. M. L. Knott, S. Stein, D. Saucier, C. Arrigoni, J. S. Gerke, M. C. Baldauf, J. Musa, M. Dallmayer, T. L. B. Hoelting, M. Moretti, , T. G. P. Grunewald

The paper identifies SOX6 as a therapeutic target in Ewing sarcoma by showing its role in elevating ROS levels, making the disease vulnerable to ROS-inducing drugs.

bioRxiv · Mar 14, 2019Cancer Biology

CIC-DUX4 expression drives the development of small round cell sarcoma in transgenic zebrafish: a new model revealing a role for ETV4 in CIC-mediated sarcomagenesis

S. Watson, G. C. Kendall, D. Rakheja, M. E. McFaul, B. W. Draper, F. Tirode, O. Delattre, J. F. Amatruda

This study establishes a zebrafish model of CIC-DUX4 sarcoma, showing that CIC-DUX4 drives tumor development and that Etv4 is critical for its oncogenic effects.

bioRxiv · Jan 12, 2019 · PreprintCancer Biology